丹参注射液联合依地酸钙钠对职业性铅中毒患者的治疗价值

Therapeutic Value of Danshen Injection Combined with Calcium Disodium Edetate on Patients with Occupational Lead Poisoning

目的探讨丹参注射液联合依地酸钙钠治疗职业性铅中毒患者的临床价值。方法选取2017年6月至2019年10月鞍山市职业病防治院收治的职业性铅中毒患者68例作为研究对象,采用随机数字表法分为对照组与观察组,各34例。对照组采用依地酸钙钠单药治疗,观察组采用丹参注射液联合依地酸钙钠治疗,比较两组患者临床疗效、血铅和尿铅值变化及不良反应情况。结果对照组、观察组治疗有效率分别为76.5%和94.1%,差异有统计学意义(P<0.05)。治疗后,观察组血铅、尿铅值低于对照组,差异有统计学意义(P<0.05)。观察组疲劳乏力、全身酸痛、恶心呕吐、食欲减退发生率低于对照组,差异有统计学意义(P<0.05)。结论丹参注射液联合依地酸钙钠用于治疗职业性铅中毒效果确切。

Objective To explore the clinical value of Danshen Injection combined with calcium disodium edetate in the treatment of patients with occupational lead poisoning. Methods A total of sixty-eight patient with occupational lead poisoning admitted to Occupational Disease Prevention and Control Institute of Anshan City from June 2017 to October 2019 were selected a the research objects, and according to random number table method, they were divided into a control group and an observation group with thirty-four cases in each group. The control group was treated with the single drug of calcium disodium edetate, and the observation group was treated with Danshen Injection combined with calcium disodium edentate. The therapeutic effect, the changes of blood lead and urine lead and the adverse reactions were compared between the two groups. Results The total effective rates of the control group and the observation group were 76.5% and 94.1% respectively, the difference was statistically significant(P<0.05). After treatment, the blood lead and urine lead of the observation group were lower than those of the control group, the difference was statistically significant(P<0.05). The incidence of fatigue, general pain, nausea and vomiting, the incidence of anorexia in the observation group were significantly lower than that in the control group(P<0.05). Conclusion Danshen Injection combined with calcium disodium edetate is effective in the treatment of occupational lead poisoning, which is worthy of clinical application.