氟西汀与氟西汀联合经颅磁刺激治疗抑郁症患者的临床疗效

Clinical Efficacy of Fluoxetine Combined with Transcranial Magnetic Stimulation in the Treatment of Depression Patients

目的探讨氟西汀与氟西汀联合经颅磁刺激治疗抑郁症患者的临床疗效。方法选取辽宁省复员军人康宁医院2018年月6至2019年12月收治的96例抑郁症患者作为研究对象,随机分为对照组与观察组,各48例。对照组采用氟西汀治疗,观察组采用氟西汀联合经颅磁刺激治疗,比较两组临床疗效、血清催乳素(PRL)水平、汉密顿抑郁量表(HAMD)评分、不良反应发生率。结果观察组治疗有效率87.50%高于对照组66.67%,差异有统计学意义(P<0.05)。治疗前,两组血清RPL水平比较,差异无统计学意义(P>0.05);治疗后,对照组血清RPL水平明显升高,差异有统计学意义(P<0.05);治疗后,观察组血清RPL水平低于对照组,差异有统计学意义(P<0.05);观察组治疗前后血清RPL水平比较差异无统计学意义(P>0.05)。两组治疗前HAMD评分比较差异无统计学意义(P>0.05);治疗后,两组HAMD评分降低,且观察组HAMD评分低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率12.50%低于对照组35.42%,差异有统计学意义(P<0.05)。结论针对抑郁症患者采用氟西汀联合经颅磁刺激治疗治疗其临床疗效优于氟西汀治疗,安全性良好。

Objective To explore the clinic effect of fluoxetine and fluoxetine combined with transcranial magnetic stimulation on depression patients. Methods A total of ninety-six depression patients from June 2018 to December 2019 admitted to Kangning Hospital of Demobilized Soldiers in Liaoning Province were selected as the research objects and were randomly divided into a control group and an observation group, with forty-eight cases in each group. The control group was treated with fluoxetine and the observation group was treated with fluoxetine combined with transcranial magnetic stimulation. The clinical efficacy, serum prolactin(PRL) level, Hamilton Depression Scale(HAMD) score, and incidence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group was 87.5% higher than that in the control group of 66.67%, the difference was statistically significant(P<0.05). There was no statistically significant difference in the serum PRL level before treatment between the two groups(P>0.05). After treatment, the serum RPL level of the control group was significantly increased, and the difference was statistically significant(P<0.05);after treatment, the serum RPL level of the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05);the serum PRL level of the observation group before and after treatment was not statistically different(P>0.05). There was no significant difference in HAMD scores between the two groups before treatment(P>0.05);after treatment, the HAMD scores of the two groups decreased, and the HAMD scores of the observation group were lower than those of the control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 12.50%, lower than that in the control group 35.42%, the difference was statistically significant(P<0.05). Conclusion For depression patients, fluoxetine combined with transcranial magnetic stimulation treatment has better clinical efficacy than fluoxetine treatment, with good safety.