生长抑制因子4与甲状腺癌的研究现状

Research status of inhibitor of growth 4 and thyroid cancer

生长抑制因子4(inhibitor of growth 4,ING4)作为抑癌基因ING家族成员,通过影响细胞周期、细胞凋亡等多种细胞过程参与肿瘤生长、侵袭和转移。甲状腺癌作为头颈部和内分泌系统最常见的恶性肿瘤,发病率逐年急剧增加,发病机制尚不明确,其发生发展涉及诸多癌基因表达上调和抑癌基因表达下调。文中结合国内外相关文献,针对ING4与甲状腺癌的研究现状进行阐述。

As a member of the tumor suppressor gene inhibitor of growth(ING)family,ING4 participates in tumor growth,invasion and metastasis by affecting various cell processes such as cell cycle and apoptosis.As the most common malignant tumor of head and neck and endocrine,thyroid cancer has increased dramatically year by year,and the pathogenesis is still unclear.Its development involves the up-regulation of oncogene expression and down-regulation of tumor suppressor gene expression.In this paper,we describe the research status of ING4 and thyroid cancer by combining relevant reports and data at home and abroad.