香兰素生物合成的研究进展

Research progress on vanillin biosynthesis

香兰素是一种十分重要的香料,在较多行业中用途广泛。天然来源的香兰素受诸多因素的限制,不能满足市场需求,因此化学法合成的香兰素是主要原料来源。近年来,随着自然资源的不断枯竭以及人们对环境保护意识的增强,通过微生物转化适宜的底物生物合成香兰素逐渐变为研究热点。本文综述了以丁香酚、异丁香酚和阿魏酸为底物的细菌、真菌生产香兰素的相关研究进展,阐述丁香酚、异丁香酚、阿魏酸产香兰素代谢途径的研究,以及生物技术在这一领域的运用。香兰素的生物合成具有广阔的发展和市场应用前景。

As a vital spice,vanillin is widely used in diverse industries.Natural vanillin cannot meet the demand of market due to many restrictions.Therefore,chemical synthesis of vanillin is the main source for market.With the continuous depletion of natural resources and the improvement of people’s awareness of environmental protection in recent years,the biological production of vanillin by microbial transformation using suitable substrates has gradually become a research hotspot.This article reviewed the related research progresses on vanillin production by bacteria and fungi with eugenol,isoeugenol and ferulic acid as substrates and also presented the investigation of the metabolic pathways of vanillin produced by eugenol,isoeugenol and ferulic acid as well as the application of biotechnology in this field.The biosynthesis of vanillin heralds vast potentials for development and considerable market prospects.