电子圆二色谱技术在微生物次级代谢产物结构研究中的应用研究进展

Progress in the application of electronic circular dichroism technology in the structural study of microbial secondary metabolites

微生物次级代谢产物的化学结构十分复杂,对其绝对构型的确定十分困难。近年来,电子圆二色谱(electronic circular dichroism,ECD)由于其用量少、精度高等优点,在测定绝对构型方面的应用越来越多,已经成为研究微生物次级代谢产物结构的重要方法。本文就电子圆二色谱在微生物次级代谢产物结构研究中的应用进行综述,以期为今后的研究奠定基础。

The chemistry construction of microbial secondary metabolites is complex,and the determination of their absolute configuration is very difficult.In recent years,electronic circular dichroism(ECD)has been used more and more in the determination of absolute configuration due to its advantages of low dosage and high accuracy,and it has become an important method to study the structure of microbial secondary metabolites.In this paper,the application of ECD in the structure of microbial secondary metabolites was reviewed,which laid a foundation for future research.