维药多脂大戟治疗白内障活性部位化学成分研究

Study on Material Basis of Anti-cataractogesis Activity of Euphorbia resinifera

目的:研究多脂大戟治疗白内障活性部位化学成分。方法:利用硅胶柱色谱、凝胶柱色谱、高效液相色谱等分离技术,对多脂大戟树脂抗白内障活性部位进行分离纯化,并通过1H-、13 C-NMR等波谱技术进行结构鉴定。结果:共鉴定6个萜类化合物,分别为eburicol(1)、羊毛甾醇(2)、ingol 7,8,12-triacetate 3-phenylacetate(3)、ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate(4)、12-O-Acetyl-8-O-tigloylingol(5)、3,12-di-O-acetylingol(6)。结论:化合物1、4、6首次从本种分离得到。

Objective To study the material basis of anti-cataractogesis activity of Euphorbia resinifera.Methods The material basis of anti-cataractogesis activity of Euphorbia resinifera were isolated by different column chromatographic techniques.Their structures were identified by a comprehensive analysis of the spectroscopic data.Results six compounds were isolated from Euphorbia resinifera and identified as eburicol(1),lanosterol(2)、ingol 7,8,12-triacetate 3-phenylacetate(3)、ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate(4)、3-O-acetyl-8-O-tigloylingol(5)、8-O-tigloylingol(6).Conclusion These compounds may relate to the anti-cataractogesis activity of Euphorbia resinifera.