丙种球蛋白联合甲泼尼龙治疗对川崎病患儿临床症状消失时间和退热时间的影响

The effect of gamma globulin combined with methylprednisolone treatment on the time to disappearance of clinical symptoms and the time to reduce fever in children with Kawasaki disease

目的探讨丙种球蛋白联合甲泼尼龙治疗对川崎病患儿临床症状消失时间、退热时间的影响。方法选取2019年1月至2019年12月本院收治的川崎病患儿64例,按照治疗方法的不同分为两组,每组32例。对照组采用丙种球蛋白治疗,观察组基于此,联合甲泼尼龙琥珀酸钠静注与甲泼尼龙片口服治疗。比较两组症状消失时间、退热时间及不良反应;分别于治疗前及治疗后第7天,测定两组血清C反应蛋白(CRP)、红细胞沉降率(ESR)与白细胞计数(WBC)。结果观察组手足硬性水肿、淋巴结大、发热、黏膜充血消退时间均显著短于对照组(P<0.05)。治疗后,观察组血清CRP水平及WBC、ESR均显著低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论丙种球蛋白与甲泼尼龙联合治疗川崎病患儿,能快速缓解其临床症状,减轻炎症反应,且不良反应轻,值得临床应用。

Objective To investigate the effect of gamma globulin combined with methylprednisolone treatment on the disappearance time of clinical symptoms and the time to reduce fever in children with Kawasaki disease.Methods 64 children with Kawasaki disease admitted to our hospital from January 2019 to December 2019 were selected and divided into two groups according to different treatment methods,with 32 cases in each group.The control group was treated with gamma globulin.Based on this,the observation group was combined with methylprednisolone sodium succinate intravenously and methylprednisolone tablets orally to compare the time to symptom disappearance,the time to fever,and adverse reactions between the two groups.Before and after treatment of the 7th day afterwards,the serum C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and white blood cell count(WBC)were measured in the two groups.Results The time for hard edema of hands and feet,large lymph nodes,fever,and mucosal congestion in the observation group was significantly shorter than that in the control group(P<0.05).After treatment,the serum CRP level,WBC and ESR of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion For children with Kawasaki disease,the combined therapy of gamma globulin and methylprednisolone can quickly relieve their clinical symptoms,reduce inflammation,and have mild adverse reactions,which is worthy of clinical application.