1.5T磁共振FOCUS扩散成像对前列腺癌的诊断分析

Analysis of 1.5 T magnetic resonance imaging FOCUS diffusion imaging in the diagnosis of prostate cancer

目的探讨1.5 T磁共振FOCUS扩散成像对前列腺癌的诊断价值。方法回顾性分析本院2017年7月至2019年7月收治的70例前列腺疾病患者的临床资料,将前列腺穿刺活检结果证实为前列腺癌的患者作为恶性组(n=33),将前列腺穿刺活检结果证实为前列腺良性病变的患者作为良性组(n=37)。两组患者均给予1.5 T磁共振FOCUS扩散成像进行诊断,比较两组DWI信号强度、ADC值、DCE-MRI的相关参数。结果在b值为50或800 s/mm^2时,恶性组的DWI信号强度均低于良性组,差异有统计学意义(P<0.05);良性组DWI信号表现为等高信号,恶性组的DWI信号表现为高信号;恶性组ADC平均值明显低于良性组,差异有统计学意义(t=2.637,P=0.010);恶性组血管外细胞间隙的体积百分比(Ve)、速率常数(Kep)、转运常数(K trans)均高于良性组,差异有统计学意义(P<0.05)。结论1.5 T磁共振FOCUS扩散成像可以客观鉴别前列腺疾病病变的良、恶性,有效提高诊断的准确性,为临床上前列腺癌早期筛查、治疗方案的制定等提供客观的参考依据,值得临床应用。

Objective To investigate the value of 1.5 T MRI FOCUS diffusion imaging in the diagnosis of prostate cancer.Methods The clinical data of 70 patients with prostate diseases admitted to our hospital from July 2017 to July 2019 were retrospectively analyzed,the patients who were confirmed with prostate cancer by prostate biopsy results were regarded as the malignant group(n=33),the patients who were confirmed with benign prostatic lesions by prostate biopsy results were regarded as the benign group(n=37).Both groups were given 1.5 T MRI FOCUS diffusion imaging for diagnosis,the related parameters of DWI signal intensity,ADC value and DCE-MRI were compared between the two groups.Results When b value was 50 or 800 s/mm^2,the DWI signal intensity of the malignant group was lower than the benign group,the difference was statistically significant(P<0.05);the DWI signal of the benign group was isointense,and that of malignant group was hyperintense;the average ADC value of the malignant group was significantly lower than the benign group(t=2.637,P<0.010);the volume percentage(VE),rate constant(kep)and transport constant(K trans)of extracellular space in the malignant group were higher than those in the benign group,the difference was statistically significant(P<0.05).Conclusion 1.5 T MRI FOCUS diffusion imaging can objectively identify benign or malignant prostate diseases,it can effectively improve the accuracy of diagnosis,and provide an objective reference for early screening and treatment of prostate cancer,and is worthy of clinical application.