IL-17和NF-κB信号通路在敌草快中毒后肾损伤中的作用及相互关系

Correlation between interleukin 17 and NF-κB signaling pathway in renal injury after diquat poisoning

敌草快是一种联吡啶类除草剂,近年来应用越来越广泛。敌草快对人体具有很强毒性,误服敌草快可导致全身多器官损伤。肾脏是敌草快中毒吸收后向体外排泄的主要器官,误服敌草快后引起的急性肾损伤逐渐引起人们的关注。敌草快中毒后能使体内细胞产生活性氧(ROS),导致氧化应激,从而提高白细胞介素17(IL-17)水平及激活核转录因子-κB(NF-κB)信号通路,IL-17与NF-κB信号通路相互作用,并作为损伤因子引起脏器结构和功能的损伤,其中包括肾脏的急性损伤。该文就敌草快中毒后肾损伤与IL-17及NF-κB信号通路之间可能的相互关系做一综述。

Diquat is a kind of bipyridine herbicide.In recent years,the application of diquat has become increasingly widespread.Diquat has severe toxicity to the human body.Misadministration of diquat can lead to multiple organ damage,in which kidney is the main organ excreted in vitro after diquat absorbed.Therefore,people have gradually paid great attention to acute kidney injury caused by improper administration of diquat.After diquat poisoning,cells in the body can produce reactive oxygen species(ROS),resulting in oxidative stress,thus increasing IL-17 and activating NF-κB signal pathway.IL-17 interacts with NF-κB signaling pathway and acts as an injury factor to cause damage to organ structure and function,including acute kidney injury.This article reviews the possible correlation between renal injury after Diquat poisoning and IL-17 and NF-κB signaling pathways.