摘要
肺微乳头腺癌作为高级别肺腺癌,具频发转移、淋巴结浸润、复发率高和总体生存率低的临床特征。该亚型肿瘤中存在特征致癌因子通路的激活和肿瘤免疫微环境的建立。本文拟对近年来微乳头腺癌的病理学表现及分子学特征研究进展作一综述,旨在加深对微乳头型病变的认识,进而为制定特异性治疗策略奠定基础。
Lung micropapillary adenocarcinoma is characterized by frequent metastasis, lymph node infiltration, high recurrence rate and low overall survival rate as a high-grade lung adenocarcinoma. Special oncogenic pathway is activated and immune microenvironment is established in this subtype of tumor. This article reviews the Pathological phenomena and molecular features of micropapillary adenocarcinoma studied in recent years, aiming to deepen the understanding of micropapillary lesions and lay the foundation for formulating specific treatment strategies.
作者
梁佳凤
吴琼
马胜林
张仕蓉
Jiafeng LIANG;Qiong WU;Shenglin MA;Shirong ZHANG(Translational Medicine Research Center,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Hangzhou 310006,China;Department of Oncology,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2020年第11期1007-1013,共7页
Chinese Journal of Lung Cancer
基金
浙江省自然科学基金(No.LY19H160032)
杭州市科技局重大项目(No.20180417A01)资助。
关键词
微乳头腺癌
转移
复发
驱动基因
免疫微环境
Micropapillary adenocarcinoma
Metastasis
Recurrence
Driver gene
Immune microenvironment
