摘要
壳聚糖及其衍生物具有无毒、生物可降解性和良好的生物相容性等特点,在药物递送系统中有良好的应用前景。叶酸受体在肿瘤细胞过表达,利用叶酸与其受体的特异性结合,可实现靶向肿瘤效应。该文综述叶酸修饰壳聚糖及其在肿瘤靶向制剂方面的研究。
Chitosan and its derivatives have non-toxic,bio-degradable and good biocompatibility,which have good application prospects in drug delivery systems.The folate receptor is overexpressed in tumor cells and utilizes the specific binding of folic acid to its receptor to achieve tumor-targeting.This article briefly summarizes the application of folic acid modified chitosan in cancer targeting agents.
作者
冯自立
孙茜
陈旺
胡代花
白瑜
朱志斌
FENG Zili;SUN Qian;CHEN Wang;HU Daihua;BAI Yu;ZHU Zhibin(State Key Laboratory of Qinba Bioresources and Eco-Environment,Hanzhong 723001,China;College of Biological Science&Engineering,Shaanxi University of Technology,Hanzhong 723001,China;Institute of Vitamin D Physiology and Application,Shaanxi University of Technology,Hanzhong 723001,China)
出处
《医药导报》
CAS
北大核心
2021年第1期94-99,共6页
Herald of Medicine
基金
国家自然科学基金资助项目(31702206)
陕西省科技厅项目(2019JQ-530)
陕西理工大学博士科研启动基金资助项目(SLGQD2017-11)。
关键词
壳聚糖
叶酸
药物载体
生物医学应用
Chitosan
Folate
Drug carriers
Biomedical applications
