卡铂按AUC计算剂量的计算方法研究进展

Research progress on calculation method of carboplatin dose according to AUC

血小板减少症是卡铂的剂量限制性毒性。根据肾小球滤过率(GFR)的变量改变影响游离卡铂曲线下面积(AUC)与所给剂量的线性关系,提出了卡铂按AUC给药的计算方法。目前临床上使用Calvert公式计算卡铂剂量,用Cockcroft-Gault公式计算出的肌酐清除率(CrCl)来代替GFR。但是Cockcroft-Gault公式在临床应用中也存在一些局限性。对卡铂的给药剂量计算策略进行综述,找到最佳剂量的计算方法,以供卡铂在临床合理用药和个体化治疗中参考。

Thrombocytopenia is the dose-limiting toxicity of carboplatin.According to the variable changes of glomerular filtration rate(GFR),it affects the linear relationship between free carboplatin AUC and the given dose.A calculation method for carboplatin administration based on AUC is proposed.At present,the Calvert formula is used to calculate the carboplatin dose in clinical practice,and the creatinine clearance(CrCl)calculated by the Cockcroft-Gault equation is used to replace GFR.However,the Cockcroft-Gault equation has some limitations in clinical application.This article reviews the calculation strategy of carboplatin dosage,and the calculation method of the optimal dose was found,which can provide reference for carboplatin in clinical rational use and individualized treatment.