HIV感染者初期情绪障碍对免疫功能影响

Effect of early emotional disorder on immune function in HIV-infected patients

目的艾滋病是由人体免疫缺陷病毒(human immunodeficiency virus,HIV)感染所引起的全身性疾病,疾病本身容易使患者出现情绪障碍。本研究对HIV感染者初期免疫功能与情绪障碍进行相关性分析。方法选取沈阳市第六人民医院2018-09-01-2019-08-31进行抗病毒治疗的HIV感染者300例为研究对象,采用抑郁自评量表(self-rating depression scale,SDS)和焦虑自评量表(self-rating anxiety scale,SAS)对患者进行情绪障碍的调查,并检测免疫指标CD4+、CD8+及CD4+/CD8+水平,分析情绪障碍与免疫指标间的关系。结果在300例HIV感染者中,无抑郁129例,占43.0%;存在抑郁者171例,占57.0%,其中轻度抑郁78例,中度抑郁75例,重度抑郁18例;无焦虑者111例,占37.0%;存在焦虑者189例,占63.0%,其中轻度焦虑97例,中度焦虑69例,重度焦虑23例。非抑郁组CD4+水平为(433.18±51.37)%,高于抑郁组的(390.57±48.61)%,差异有统计学意义,t=3.783,P<0.001;CD8+水平为(927.54±192.76)%,低于抑郁组的(1062.87±213.45)%,差异有统计学意义,t=2.920,P=0.005。非焦虑组CD4+水平为(442.59±53.21)%,高于焦虑组的(386.33±46.98)%,差异有统计学意义,t=4.906,P<0.001;CD8+水平为(914.17±188.64)%,低于抑郁组的(1016.75±227.16)%,差异有统计学意义,t=2.060,P=0.043。结论抑郁情绪及焦虑情绪患者较无情绪障碍患者相关免疫指标明显异常,提示HIV感染者初期免疫功能与情绪障碍有关联。

OBJECTIVE AIDS is a systemic disease caused by human immunodeficiency virus(HIV)infection.The disease itself can easily cause emotional disorders in patients.This study analyzed the correlation between the initial immune function and mood disorders of HIV-infected patients.METHODS From September 1,2018 to August 31,2019,300 HIV-infected patients who were admitted to the Sixth People’s Hospital of Shenyang City for antiviral treatment were selected as the research subjects.Emotional disorders were estimated using self-rating depression scale(SDS)and self-rating anxiety scale(SAS)score.The levels of immune indicators CD4^+,CD8^+,and CD4^+/CD8^+were detected and the relationship between emotional disorders and immune indicators were analyzed.RESULTS Among 300 HIV-infected persons,there were 129 cases without depression(43.0%)and 171 cases with depression(57.0%),including 78 cases with mild depression,75 cases with moderate depression,and 18 cases with severe depression.There were 189 cases(63.0%)with anxiety,including 97 cases of mild anxiety,69 cases of moderate anxiety and 23 cases of severe anxiety.The CD4^+level in the non-depression group was 433.18±51.37,which was higher than that of the depression group 390.57±48.61,the difference was statistically significant,t=3.783,P<0.001.The CD8^+level was 927.54±192.76,lower than the depression group that of 1062.87±213.45,the difference was statistically significant,t=2.920,P=0.005.The CD4^+level in the non-anxiety group was 442.59±53.21,higher than that of the anxiety group 386.33±46.98,and the difference was statistically significant,t=4.906,P<0.001.The CD8^+level was 914.17±188.64,lower than the depression group 1016.75±227.16,and the difference was statistically significant,t=2.060,P=0.043.CONCLUSION Patients with depression and anxiety have significantly more abnormal immune indicators than patients without mood disorders,suggesting that the initial immune function of HIV-infected patients is related to mood disorders.