慢性子宫内膜炎在生殖领域中的研究进展

Research progress of chronic endometritis in reproduction

慢性子宫内膜炎(chronic endometritis,CE)是由各种病原体引起的子宫内膜持续且隐匿的炎症。CE患者大多缺乏明显的症状、体征或症状轻微,临床上往往易被忽视。病理检查发现子宫内膜间质内浆细胞浸润是诊断CE的金标准。宫腔镜及病理组织学检测发现不少不孕症女性患有这种子宫内膜病变,而这种病变应用超声和造影等检查均难以发现。越来越多的报道显示CE会造成不孕、复发性流产、行体外受精-胚胎移植(IVF-ET)者反复胚胎种植失败等。抗生素治疗后这类患者会获得较高的种植率和临床妊娠率。本文旨在对CE的病因、诊断、治疗及在生殖等相关领域的研究进展做一综述。

Chronic endometritis(CE)is a disease of persistent and mild inflammation in endometrium caused by many kinds of pathogens.CE is often missed during the clinical practice for the hidden symptoms or even no symptom of the patients.Histological detection of plasma cells in the stromal area of the endometrium is still the gold standard test for diagnosis of CE.The application of hysteroscopy and histological test have revealed that CE was widespread in infertility women,which is hard to be detected by routine examination,such as ultrasound and hysteronsalpingography(HSG).More and more evidences demonstrated that CE was associated with the infertility,repeated implantation failure and recurrent pregnancy loss.It has been proved that the clinical pregnancy rate and the implantation rate of IVF patients could be improved after treatment with antibiotic.The aim of this review is to address the etiology,diagnosis,treatment and current literature surrounding CE and highlight recent advances in reproduction.