女性高雄激素对妊娠和子代影响的研究进展

Effects of high level of androgens on pregnancy and offsprings in female

雄激素对女性的生殖健康有重要作用。雄激素过多会影响糖脂蛋白质代谢及生殖系统的功能。妊娠期雄激素过多会影响母体的健康,导致流产等不良妊娠结局以及妊娠期高血压疾病、妊娠期糖尿病、早产等妊娠期并发症。过量的雄激素还会通过胎盘影响胎儿各系统的生长发育,对胎儿在宫内的发育及子代出生后的健康产生不良影响。本文从高雄激素对妊娠和子代的影响方面作一综述。

Androgen has an important impact on women's reproductive health.Hyperandrogenism can cause various metabolism disorders and damages reproductive system functions.Hyperandrogenism during pregnancy will not only affect the health of the mother,leading to adverse pregnancy outcomes such as abortion,as well as pregnancy complications such as hypertensive disorder complicating pregnancy,gestational diabetes,and premature delivery.Exposure of the fetus to excess androgen can also affect the development of fetal systems,and therefore adversely affect the health of the fetus and even the postnatal offsprings.This article reviews the effects of high level of androgens on pregnancy and offsprings.