癌症患者高强度间歇性训练效果的Meta分析

Effectiveness of high intensity interval training in cancer patients:a meta-analysis

目的评价高强度间歇训练在癌症患者中的应用效果.方法计算机检索Cochrane Library、PubMed、Embase、Web of Science、CINAHL、中国知网、万方、维普数据库、中国生物医学文献数据库中关于高强度间歇训练应用于癌症患者的随机对照试验,检索时限为建库至2019年10月.经2名研究者筛选文献、提取信息与质量评价后,采用RevMan 5.3软件进行Meta分析.结果最终纳入8项研究,共970例患者.Meta分析结果显示,高强度间歇训练能提高患者的峰值摄氧量和肌肉力量[SMD=0.23,95%CI(0.07,0.39),P<0.01;MD=2.38,95%CI(1.08,3.68),P<0.001],改善患者的癌因性疲乏情况[SMD=-0.26,95%CI(-0.48,-0.04),P=0.02],提高患者的睡眠质量和生活质量[SMD=-0.25,95%CI(-0.47,-0.04),P=0.02;SMD=0.28,95%CI(0.13,0.43),P<0.001],对于焦虑、抑郁情绪作用效果不明显[SMD=0.05,95%CI(-0.12,0.22),P=0.54;MD=-0.08,95%CI(-0.25,0.09),P=0.34].结论高强度间歇训练有效增强癌症患者的峰值摄氧量和肌肉力量,改善患者的睡眠质量,减轻患者的癌因性疲乏,提高其生活质量.由于本研究所纳入的均为国外文献,且部分结局指标间存在异质性,故未来国内可开展小样本的试点研究,进一步探究高强度间歇训练在国内癌症患者中的适用性及可行性,为癌症患者实施高强度间歇训练提供更多循证依据.

Objective To evaluate the effectiveness of high intensity interval training(HIIT)in cancer patients.Methods We searched databases including Cochrane Library,PubMed,Embase,Web of Science,CINAHL,CNKI,Wanfang,VIP,and CBM from inception to January 2019,and included randomized controlled trials(RCTs)reporting the effectiveness of HIIT in cancer patients.Literature screening,information extraction and quality evaluation were conducted by 2 reviewers,and RevMan 5.3 software was adopted for meta-analysis.Results A total of 8 RCTs with 970 patients were included in this meta-analysis.The results showed that HIIT could increase VO2peak,muscular strength[SMD=0.23,95%CI(0.07,0.58),P<0.01;MD=2.38,95%CI(1.08,3.68),P<0.001]and improve cancer related fatigue[SMD=-0.26,95%CI(-0.48,-0.04),P=0.02],and improve quality of sleep and quality of life[SMD=-0.25,95%CI(-0.47,-0.04),P<0.05;SMD=0.28,95%CI(0.13,0.43),P<0.001].The effectiveness on anxiety and depression was not statistically significant[SMD=0.05,95%CI(-0.12,0.22),P=0.54;MD=-0.08,95%CI(-0.25,0.09),P=0.34].Conclusion HIIT is effective on improving VO2peak,muscle strength,quality of sleep,cancer related fatigue and quality of life.As all the studies included in this meta-analysis are foreign literature with heterogeneity among some outcome indicators,pilot trials with small samples can be carried out in the future to further explore the applicability and feasibility of HIIT in cancer patients in China,so as to provide more evidence for the implementation of HIIT for cancer patients.