前列腺特异性抗原、睾酮和D二聚体水平在前列腺癌诊断中的价值分析

Diagnostic value of PSA,testosterone and D-D for prostate cancer

目的探讨前列腺特异性抗原(PSA)、睾酮(T)和D二聚体(D-D)水平在前列腺癌(PCa)诊断中的价值。方法选取2015年9月至2019年9月间陕西省第四人民医院收治的60例PCa患者为PCa组,选取同期58例前列腺增生(BPH)患者为BPH组,另选取同期60例健康体检者为对照组。采用全自动酶联荧光分析仪检测三组受试者PSA水平,采用全自动凝血酶仪测定D-D水平,采用化学发光免疫吸附法测定T水平,比较三组受试者的血清PSA、D-D和T水平。结果PCa组患者PSA和D-D水平均高于BPH组和对照组,T水平低于BPH组和对照组;BPH组患者PSA和D-D水平均高于对照组,T水平低于对照组,差异均有统计学意义(均P<0.05)。随着PCa患者临床分期升高,PSA和D-D水平均升高,T水平降低,差异均有统计学意义(均P<0.05)。受试者工作曲线分析显示,PSA、D-D和T诊断前列腺癌的曲线下面积均>0.9,诊断的准确性、灵敏度和特意度均较高。结论前列腺特异性抗原、睾酮和D二聚体在前列腺癌中呈高表达,且随着肿瘤分期增加明显升高,对前列腺癌的诊断有较高的准确性。

Objective To investigate the diagnostic value of prostate-specific antigen(PSA),testosterone(T)and D dimer(D-D)levels for prostate cancer(PCa).Methods Sixty patients with prostate cancer admitted to The Fourth People's Hospital of Shaanxi from September 2015 to September 2019 were selected as the PCa group,58 patients diagnosed with prostatic hyperplasia during the same period were selected as the prostatic hyperplasia group(BPH group),and 60 healthy individuals who received physical examination during the same period were selected as the control group.PSA level was determined by full-automatic enzyme-linked fluorescence immunoassay,D-D level by full-automatic thrombin assay,and T level by chemiluminescence immunosorbent assay.PSA,T and D-D levels were compared among the three groups.Results PSA and D-D levels were significantly higher in PCa group than those in BPH group and control group,and T levels were significantly lower in PCa group than those in BPH group and control group(all P<0.05).PSA and D-D level was significantly higher in BPH group than in control group and T level was lower in BPH group than in control group(all P<0.05).With the increase in the clinical stage in PCa patients,PSA and D-D levels were significantly increased and T levels were significantly decreased(all P<0.05).ROC curve analysis showed that the area under the curve of PSA,D-D and T for the diagnosis of prostate cancer was>0.9,with high diagnostic accuracy,sensitivity and specificity.Conclusion PSA,D-D and T are highly expressed in prostate cancer,and their levels are significantly increased with the increase of tumor stage,which has high accuracy for the diagnosis of prostate cancer.