摘要
内皮-单核细胞激活多肽Ⅱ(endothelial monocyte-activating polypeptide Ⅱ,EMAP Ⅱ)是一种能诱导内皮细胞产生组织因子促凝活性、趋化单核细胞和粒细胞诱导炎症反应的蛋白。EMAP Ⅱ是由其前体蛋白pro-EMAP Ⅱ在一定条件下酶解形成,可作用于内皮细胞、单核细胞、巨噬细胞、成纤维细胞和肿瘤细胞等,发挥广泛的生物学功能。目前国内外关于EMAP Ⅱ的研究多集中在肿瘤、糖尿病、动脉粥样硬化、慢性心肌梗塞、肺损伤等方面。该文将从EMAP Ⅱ的结构、功能及分布、抑制血管新生的详细机制及其与疾病的相关性等方面详细阐述EMAP Ⅱ与血管新生的研究进展。
Endothelial monocyte-activating polypeptide Ⅱ(EMAP Ⅱ)is a kind of protein which can induce the endothelial cells to produce tissue factor coagulant activity and make chemotaxis act on monocytes and granulocytes to induce inflammation.EMAP Ⅱ is formed by its precursor protein(pro-EMAP Ⅱ)under certain condition,acting on the endothelial cells,monocytes,macrophages,fibroblasts,tumor cells,and so on,which can play a wide range of biological functions.Nowadays,the research about the EMAP Ⅱ mostly focus on tumor,diabetes,atherosclerosis,chronic myocardial infarction,lung injury,and so on.This article is about the research progress of EMAP Ⅱ and angiogenesis from the aspects of the structure,function and distribution of EMAP Ⅱ as well as its detailed mechanism of inhibiting angiogenesis and its correlation with disease.
作者
李春(综述)
王华(审校)
Li Chun;Wang Hua(Department of Pediatric Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《国际儿科学杂志》
2020年第11期773-777,共5页
International Journal of Pediatrics
基金
国家重点研发计划(2016YFC1306203)。
