儿童幽门螺杆菌感染相关疾病的研究进展

Advances in Helicobacter pylori infection-associated diseases in children

我国儿童幽门螺杆菌(Helicobacter pylori,H.pylori)感染率较高。目前研究表明,儿童H.pylori感染的特点包括耐受性的免疫应答和较轻的炎症反应,内镜下常表现为结节性胃炎,部分患儿可发生消化性溃疡。儿童H.pylori感染与胃食管反流病、消化不良、复发性腹痛等消化系统疾病的关系尚存在争议,与血液系统疾病、过敏性疾病、生长发育等存在相关,并可与胃肠道微生态相互影响,但其中的因果关系和内在机制尚未明确,需要进一步的研究证实。

The prevalence of Helicobacter pylori(H.pylori)infection among children remains high in China.Children infected with H.pylori reveal a tolerant immune response and a mild inflammatory response according to recent studies.Nodular gastritis is the most common endoscopic manifestation of H.pylori infection in children,and peptic ulcer occurs in a small number of pediatric patients.The relationship between H.pylori infection and digestive diseases,including gastroesophageal reflux disease,dyspepsia,and recurrent abdominal pain remains controversial.Numerous studies have confirmed that H.pylori infection is also associated with some blood system diseases,allergic diseases,and children's growth,and could interacts with gut microbiota.However,the causality between H.pylori and diseases mentioned are not fully confirmed,and the path・ogenesis mechanisms is still unclear.Therefore,further studies are needed to elicit the causality and mechanisms.