多索茶碱联合氨溴索治疗小儿哮喘的疗效及其对T淋巴细胞亚群和肺功能的影响

Effect of doxofylline combined with ambroxol in treatment of childhood asthma and its effect on T lymphocyte subsets and lung function

目的探讨多索茶碱联合氨溴索对小儿哮喘患者的临床疗效及其对T淋巴细胞亚群和肺功能的影响。方法选取格尔木市人民医院2017年1月—2019年1月收治的60例小儿哮喘患者作为研究对象,按照随机双盲法将患儿分为对照组和观察组,每组各30例。对照组患儿静脉滴注盐酸氨溴索注射液,将药物加入到葡萄糖注射液(或生理盐水)中,2~6岁儿童:7.5 mg/次,3次/d;2岁以下儿童:7.5 mg/次,2次/d。观察组患者在对照组治疗的基础上静脉滴注多索茶碱注射液,100 mg/次,以25%葡萄糖注射液稀释至40 mL,时间应在20 min以上。两组患者均以2周为1个疗程,两组患者均治疗1个疗程。观察两组患者的临床疗效,同时比较两组治疗前后的T淋巴细胞亚群和肺功能的水平。结果治疗后,观察组患者的治疗总有效率为93.3%,明显高于对照组的73.3%(P<0.05)。治疗后,两组患者各项T淋巴细胞亚群水平明显优于治疗前(P<0.05),且观察组各项T淋巴细胞亚群水平明显优于对照组(P<0.05)。治疗后,两组患者各项肺功能指标均较治疗前改善(P<0.05),而观察组患者各项肺功能指标治疗后比治疗前变化幅度明显大于对照组(P<0.05)。结论多索茶碱联合氨溴索治疗小儿哮喘可获取显著的治疗效果,可有效改善患者T淋巴细胞亚群水平,改善肺功能,具有重要的临床价值。

Objective To investigate the clinical effect of doxofylline combined with ambroxol on children with asthma and its effect on T lymphocyte subsets and lung function. Methods A total of 60 pediatric asthma patients admitted to Golmud People’s Hospital from January 2017 to January 2019 were selected as the research objects. According to the randomized double-blind method, the children were divided into the control group and the observation group, with 30 patients in each group. Children in the control group were iv administered with Ambroxol Hydrochloride Injection, and the drug was added to glucose injection(or normal saline).Children aged two to six years were 7.5 mg/time, three times daily. Children under two years were 7.5 mg/time, twice daily. Children in the observation group were iv administered with Doxofylline Injection on the basis of control group, 100 mg/time, and diluted with 25% glucose injection to 40 mL for the time of more than 20 min. Patients in two groups were received one course of treatment for 2 weeks. The clinical efficacy in two groups was observed, and the T lymphocyte subsets and lung function levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 93.3%,which was significantly higher than 73.3% in the control group(P < 0.05). After treatment, the levels of T lymphocyte subsets in two groups were significantly better than those before treatment(P < 0.05), and the levels of T lymphocyte subsets in the observation group were significantly better than those in the control group(P < 0.05). After treatment, lung function indicators in two groups were improved compared with that before treatment(P < 0.05), while the changes of lung function indicators in the observation group were significantly larger than those in the control group(P < 0.05). Conclusion Doxofylline combined with ambroxol in treatment of childhood asthma can obtain significant therapeutic effect, can effectively improve the level of T lymphocyte subsets,improve lung function, has important clinical value.