四红祛斑汤联合脊柱梳理治疗气滞血瘀型黄褐斑患者的临床疗效

Clinical efficacy of Sihong Quban Decoction combined with spinal carding in the treatment of patients with qi stagnation and blood stasis type chloasma

目的分析四红祛斑汤联合脊柱梳理治疗气滞血瘀型黄褐斑的效果。方法纳入2015年12月至2018年3月黑龙江省中医药科学院南岗分院入院治疗的86例气滞血瘀型黄褐斑患者,随机数字表法分为2组,每组43例,对照组采用常规治疗(维生素C、维A酸),观察组在此基础上采用四红祛斑汤联合脊柱梳理治疗。4周1个疗程,连续治疗2个疗程。对比2组患者治疗前后皮损颜色积分、皮损面积积分、皮损总积分、中医兼症积分、治疗总有效率、皮肤水分含量、皮肤弹性和血清超氧化物歧化酶(SOD)、一氧化氮(NO)水平;对比2组患者治疗后6个月复发率。结果治疗后2组患者的皮损颜色积分、皮损面积积分、皮损总积分及中医兼症积分均较治疗前降低,观察组较对照组积分低,差异具有统计学意义(P<0.05);观察组治疗总有效率(86.0%)较对照组(65.1%)高,差异具有统计学意义(P<0.05);治疗后2组患者皮肤水分含量及弹性均有所改善,观察组较对照组高,差异具有统计学意义(P<0.05);治疗后2组患者血清SOD水平升高,NO水平降低,观察组较对照组改善显著,差异具有统计学意义(P<0.05);观察组复发率(4.6%)较对照组复发率(27.9%)低,差异具有统计学意义(P<0.05)。结论四红祛斑汤联合脊柱梳理治疗气滞血瘀型黄褐斑能进一步缓解中医学症状,提高疗效,改善皮肤状态,降低NO水平,升高血清SOD水平,降低短期复发率,值得推广。

Objective To analyze the effect of Sihong Quban Decoction combined with spinal carding on the treatment of qi stagnation and blood stasis type chloasma.Methods 86 patients with chloasma were enrolled in the hospital from December 2015 to March 2018.The patients were randomly divided into two groups.The control group received routine treatment(vitamin C,vitamin A acid).The observation group was treated with Sihong Quban Decoction combined with spinal carding on the basis of control group.The skinlesion color scores,skin lesion area scores,total skin lesion scores and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared between the two groups.The total effective rate was compared between the two groups.The skin moisture content,skin elasticity and serum superoxide dismutase(SOD)and nitric oxide(NO)were compared before and after treatment.The recurrence rate was compared at 6 months after treatment in both groups.Results After treatment,the skin lesion color scores,skin lesion area scores,total skin lesion scores,and TCM scores were decreased,and the observation group was lower than the control group(P<0.05).The total effective rate of treatment in the observation group(86.0%)was higher than that in the control group(65.1%)(P<0.05).After treatment,the skin moisture content and skin elasticity of the two groups were improved,and the observation group was higher than the control group(P<0.05).After treatment,serum SOD levels increased and NO levels decreased.Serum SOD was higher and NO was lower in the observation group than the control groub(P<0.05).The recurrence rate of the observation group(4.6%)was lower than that of the control group(27.9%)(P<0.05).Conclusion Sihong Quban Decoction combined with spinal carding treatment for qi stagnation and blood stasis type chloasma can further alleviate TCM symptoms,improve curative effect,improve skin condition,decrease serum NO level,increase serum SOD level and reduce short-term recurrence rate.It is worthy of promotion.