参灵斛保健含片的制备工艺

Preparation technology of health-care buccal tablets of Ginseng-Ganoderma-Dendrobium

目的对参灵斛保健含片的制备工艺进行研究。方法采用直接压片法制备参灵斛保健含片。以感官评价、含片的成型性、休止角、硬度、片重重量差异、崩解时限为评价指标,考察辅料抗性糊精、异麦芽酮糖醇、硬脂酸镁的添加量。结果制备参灵斛保健含片的较佳工艺条件为:参灵斛浸膏粉:抗性糊精:异麦芽酮糖醇=5:1:4(m:m:m),硬脂酸镁添加量为1%(m:m),采用直接压片法生产,控制压片压力为50~60N。结论采用此配方加工制得的含片外观形性状、片重差异、崩解时限等均符合中国药典对含片的质量要求。

Objective To study the preparation technology of health-care buccal tablets of Ginseng-Ganoder ma-Dendrobium. Methods Tablets of Ginseng-Ganoderma-Dendrobium were prepared by direct compression method. By taking sensory evaluation, molding property, angle of repose, hardness, weight difference and melting situation of tablet as indexes, the optimal prescription was finally determined by adopting the single factor method to investigate the amount of excipient resistant dextrin, isomaltool and magnesium stearate. Results The optimum technological conditions for preparing Ginseng-Ganoderma-Dendrobium health buccal tablets were as follows: Ginseng-Ganoderma-Dendrobium:resistant dextrin:isomaltool=5:1:4(m:m:m), magnesium, stearate 1%(m:m). The direct tablet pressing method was used, and the pressure of tablet pressing was controlled to be 50-60 N. Conclusion The appearance, shape, weight difference and disintegration time of buccal tablets processed with this formula can meet the requirements of Chinese pharmacopoeia.