白细胞介素-6/信号转导及转录活化因子3信号传导通路在心脏修复中的作用

Effect of interleukin-6/signal transducer and activator of transcription 3 signaling pathway on heart repair

白细胞介素-6(IL-6)能修复多种组织损伤。IL-6信号通路中的关键转录因子——信号转导及转录活化因子3(STAT3)具有保护心脏的功能。研究发现,IL-6通过介导STAT3信号传导通路(IL-6/STAT3信号传导通路),在心脏创伤、心肌炎、心脏衰竭等多种心脏疾病造成的损伤中发挥促进心脏修复的作用。深入研究IL-6/STAT3信号传导通路对心脏疾病有积极的治疗意义,现就该通路在心脏修复中的作用进展进行综述。

Interleukin-6(IL-6)is involved in the repair of various tissues.As a key transcription factor in IL-6 pathway,signal transducer and activator of transcription 3(STAT3)is required for heart protection.By inducing STAT3 activation,IL-6 signaling pathway could repair the cardiac damage in the healing process of many kinds of heart diseases,including cardiac injury,myocarditis and heart failure.Therefore,researches on the effect of IL-6/STAT3 pathway on heart repair has potential therapeutic implications for heart diseases.