动脉粥样硬化疫苗的研究进展

Progress on atherosclerosis vaccine

动脉粥样硬化是动脉壁免疫系统介导的炎症性疾病。动脉壁特异性和非特异性免疫系统对许多内源性和外源性抗原都有免疫反应。已有研究表明免疫系统在动脉粥样硬化进程中一方面促进动脉粥样硬化,另一方面延缓动脉粥样硬化。因此,通过针对抗原的主动免疫调节可以改变动脉粥样硬化的进程。本文讨论了特异性和非特异性免疫系统在动脉粥样硬化进程中的双重作用,介绍了已经在实验室阶段制成的疫苗以及在实验模型中成功延缓动脉粥样硬化进程的抗原的研究,探讨了动脉粥样硬化疫苗临床应用的前景和挑战。

Atherosclerosis is an inflammatory disease which mediated by the immune system of the arterial wall.Specific and non-specific immune systems of arterial wall showed positive immunore action with many endoge⁃nous and exogenous antigens.Studies have shown that the immune system promotes atherosclerosis on the one hand and delays atherosclerosis on the other.Therefore,the progress of atherosclerosis can be regulated through activating immune regulation.In this review,the double effects of specific and non-specific immune systems on the process of atherosclerosis were discussed.The studies of those antigen which have been made into vaccines and successfully delayed the process of atherosclerosis in laboratory models were introduced.And the prospects and challenges for future clinical application of atherosclerosis vaccines were discussed in this review.