四川省南充市无症状儿童幽门螺杆菌感染的流行病学调查

Epidemiological investigation of Helicobacter pylori infection rate in asymptomatic children in Nanchong City,Sichuan Province

目的探讨四川省南充市无症状儿童幽门螺杆菌(H.pylori)感染的流行病学特点及其影响因素。方法选择2016年1月至2019年10月在南充市中心医院进行健康体检的无消化道症状儿童1 247例进行研究。受试儿童受检前空腹或禁食2 h以上,行13C-尿素呼气试验。以自制问卷对受试对象家长进行问卷调查。单因素分析采用χ^2检验,多因素分析采用Logistic回归分析。结果本次调查共发放问卷1 247份,回收有效问卷1 228份,回收率为98.48%,共223例受调查儿童H.pylori阳性,阳性率为18.16%(223/1228)。单因素分析结果显示,儿童性别、父亲文化程度、家庭成员人数、家庭月收入、公用餐具不同情况的无症状儿童H.pylori感染率差异无统计学意义(P>0.05)。儿童年龄、母亲文化程度、直系家属胃病史、主要照顾者、居住地、幼儿时期口嚼喂食、饭前便后洗手、啃手指、吃零食、公用洗漱用具不同情况的无症状儿童H.pylori感染率差异具有统计学意义(P <0.05)。多因素分析结果显示母亲文化程度大专及以上、饭前便后有洗手为四川省南充市无症状儿童H.pylori感染的保护因素,儿童年龄8~14岁、直系家属有胃病史、幼儿时期有口嚼喂食、啃手指及公用洗漱用具为危险因素(P <0.05)。结论四川省南充市无症状儿童H.pylori感染率为18.16%,主要受母亲文化程度、饭前便后洗手、儿童年龄、直系家属有胃病史、幼儿时期口嚼喂食、啃手指及公用洗漱情况等因素的影响,临床对此类患儿进行干预时上应注意上述因素的干预以降低感染率。

Objective To explore the epidemiological characteristics of Helicobacter pylori( H.pylori) infection rate and its influencing factors in asymptomatic children in Nanchong City,Sichuan Province.Methods A total of 1,247 children without gastrointestinal symptoms who underwent a health checkup in our hospital from January 2016 to October 2019 were selected for study.Before the test,the children were fasted or fasted for more than 2 hours.The 13 C breath test was performed.A self-made questionnaire was used to survey the parents of the test subjects.Univariate analysis was performed by χ^2 test,and multivariate analysis was performed by Logistic regression analysis.Results A total of 1247 questionnaires were distributed and 1,228 valid questionnaires were recovered.The recovery rate was 98.48%.A total of 223 children were positive for H.pylori infection,and the positive rate was18.16%( 223/1228).The univariate analysis showed that there was no significant difference in H.pylori infection rates among asymptomatic children with different children’s gender,father’s education,number of family members,monthly household income,and common tableware( P > 0.05).Children’s age,mother’s education level,family history of immediate family members,main caregiver,place of residence,chewing and feeding in early childhood,washing hands before and after meals,pinching fingers,snacks,and public toilets,and H.pylori infection rates in asymptomatic children The difference was statistically significant( P < 0.05).The results of multivariate analysis showed that monthers with college education or above,washing hands before and after eating were the protective factors of H.pylori infection in asymptomatic children in Nanchong City,Sichuan Province.The risk factors were children’s age of 8-14 years,family members with history of stomach disease,chewing and feeding in childhood,gnawing fingers and public washing utensils( P <0.05).Conclusion The infection rate of H.pylori in asymptomatic children in Nanchong City,Sichuan Province is 18.16%,which is mainly affected by the mother’s education level,washing hands before and after meals,age of children,history of suffocation accelerated gastropathy,chewing and feeding in childhood,gnawing fingers and public washing and rinsing.In order to reduce the infection rate,we should pay attention to the above-mentioned factors in clinical intervention.