唾液腺癌分子病理诊断进展

Advances in Molecular Pathological Diagnosis of Salivary Gland Carcinomas

近年来唾液腺癌的分子检测取得了巨大的进展,越来越多的遗传学改变被发现。这些遗传学改变对唾液腺癌的病理诊断起了重要的辅助作用,也对唾液腺癌的命名、分类及新类型肿瘤的发现产生着影响。本文对近年来发现的唾液腺癌中重要遗传学改变及部分肿瘤中相应蛋白的表达变化进行介绍,这些变化在相关肿瘤的病理诊断、预后评估、靶向治疗中都发挥着重要的作用。

In recent years,great progress has been achieved in molecular detection of salivary gland carcinomas,and more and more genetic changes have been found.These genetic changes play an important role in the pathological diagnosis of salivary gland carcinomas,and also have an impact on the naming,classification and discovery of new types of salivary gland carcinomas.In this review,we will introduce the important genetic alterations in salivary gland carcinomas and the changes of corresponding protein expression in some tumors.These changes play an important role in the pathological diagnosis,prognosis evaluation and targeted treatment of the related carcinomas.