基于质谱的高通量蛋白质组学技术对甲状腺癌精准诊疗的推动

The promotion of precise diagnosis and treatment of thyroid cancer by mass spectrometry-based high throughput proteomics technologies

甲状腺癌是常见的内分泌恶性肿瘤,发病率逐年增加。深入了解甲状腺癌发生发展机制对提高诊断准确性、进行精准风险分层和实现个性化治疗至关重要。近年来,随着质谱相关技术的不断发展,基于不同标本类型(细胞、组织、血清和尿液)的多种蛋白质组学分析方法已被广泛应用于甲状腺癌的研究中,从阐明发病机制、诊断分型、预测预后和靶向治疗等方面积极地推动了甲状腺癌精准诊疗的发展。

Thyroid cancer is a common endocrine malignant tumor,and its incidence is increasing year by year.Understanding the pathogenesis of thyroid cancer is essential for improving the accuracy of diagnosis,precise risk stratification,and the realization of personalized treatment.Recently,with the consistent development of mass spectrometry-related technologies,a variety of proteomics analysis methods based on different specimen types(cells,tissues,serum and urine)have been widely used in the research of thyroid cancer,thereby actively promote the development of precision diagnosis and treatment of thyroid cancer through elucidating the pathogenesis,diagnostic classification,prognosis prediction and targeted therapy etc.