臭氧大自血疗法联合艾司唑仑对失眠症患者临床疗效、睡眠质量及生活质量的影响

Clinical Effect of Ozone Autohemotherapy Combined with Estazolam and Its Effect on Sleep Quality and Quality of Life of Patients with Insomnia

目的分析臭氧大自血疗法联合艾司唑仑对失眠症患者临床疗效、睡眠质量及生活质量的影响。方法选择2019年1月—2020年4月收治的失眠症患者87例,对其资料进行回顾性分析。按治疗方法的不同将纳入患者分为联合组44例及单一组43例。单一组给予艾司唑仑治疗,联合组给予臭氧大自血疗法联合艾司唑仑治疗。比较2组临床疗效、抑郁自评量表(PHQ-9)、沃里克-爱丁堡积极心理健康量表(WEMWBS)、匹兹堡睡眠质量指数(PSQI)、失眠严重程度指数(ISI)、生存质量测定量表(WHOQOL-BREF)评分,并观察不良反应发生情况。结果治疗后,2组PSQI、ISI积分以及PHQ-9评分较治疗前均显著下降,且联合组下降幅度较单一组大(P<0.01)。治疗后,2组WEMWBS、WHOQOL-BREF评分较治疗前显著升高,且联合组升高幅度较单一组大(P<0.01)。联合组临床总有效率显著高于单一组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论臭氧大自血疗法联合艾司唑仑治疗可显著提高失眠症患者的WHOQOL-BREF评分,降低PSQI积分,临床疗效较单一艾司唑仑治疗佳,且安全性高。

Objective To analyze the clinical effect of Ozone Autohemotherapy combined with Estazolam and its effect on sleep quality and quality of life of patients with insomnia.Methods Eighty-seven patients with insomnia treated from January 2019 to April 2020 were selected and their data were retrospectively analyzed.According to different treatment methods,the patients include were divided into combination group(n=44)and single treatment group(n=43).The single treatment group was given Estazolam,and the combination group was given Ozone Autohemotherapy combined with Estazolam.The clinical efficacy,patient health questionnaire-9(PHQ-9),Warwick-Edinburgh mental well-being scale(WEMWBS),Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and WHOQOL-BREF scores of the two groups were compared,and the occurrence of adverse reactions was observed.Results After treatment,the PSQI,ISI and PHQ-9 scores of the two groups were decreased significantly compared with those before treatment,and the decrease of the combination group was greater than that of the single treatment group(P<0.01).After treatment,the WEMWBS and WHOQOL-BREF scores in the two groups were significantly higher than those before treatment,and the increase in the combination group was greater than that that in the single treatment group(P<0.01).The total effective rate of the combination group was significantly higher than that of the single treatment group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ozone Autohemotherapy combined with Estazolam can significantly improve the WHOQOL-BREF score and reduce the PSQI score in the treatment of patients with insomnia,the clinical effect is better than that of a single Estazolam treatment,and the safety is good.