不同剂量阿托伐他汀治疗老年稳定型心绞痛的疗效观察

Observation on the Efficacy of Different Doses of Atorvastatin in the Treatment of Elderly Stable Angina Pectoris

目的探讨不同剂量阿托伐他汀治疗老年稳定型心绞痛的临床效果。方法纳入我院2018年3月至2018年9月收治的老年稳定型心绞痛患者160例作为研究对象。根据阿托伐他汀的用量分为A组(n=45,小剂量)、B组(n=50,常规剂量)和C组(n=65,大剂量)。持续治疗4周后,比较三组的治疗效果。结果C组的治疗总有效率(95.38%)最高,其次为B组(90.00%),A组(77.78%)最低,差异有统计学意义(P<0.05)。治疗后,C组的MDA水平低于A组、B组,SOD、cTnI水平高于A组、B组,差异有统计学意义(P<0.05)。三组的不良反应发生率无显著差异(P>0.05)。结论大剂量阿托伐他汀治疗老年稳定型心绞痛的效果显著,可有效改善患者的氧化应激水平,降低心肌损伤程度,且安全性高。

Objective To explore the efficacy of different doses of atorvastatin in the treatment of elderly stable angina pectoris.Methods 160 cases of elderly patients with stable angina pectoris admitted to our hospital from March 2018 to September 2018 were selected as study objects.According to the dose of atorvastatin,all cases were divided into group A(n=45,low dose),group B(n=50,conventional dose)and group C(n=65,high dose).After 4 weeks of continuous treatment,the treatment effects of the three groups were compared.Results The total effective rate of treatment in group C(95.38%)was the highest,followed by group B(90.00%),and group A(77.78%)was the lowest,with statistically significant differences(P<0.05).After treatment,the level of MDA of group C was lower than that of group A and group B,while the levels of SOD and cTnI were higher than those of group A and group B,with statistically significant differences(P<0.05).No significant difference was found in the incidence of adverse reactions among the three groups(P>0.05).Conclusions High dose of atorvastatin in the treatment of elderly stable angina pectoris has significant effect and high safety,which can effectively improve the level of oxidative stress,and reduce the degree of myocardial injury of patients.