阿立哌唑联合碳酸锂治疗急性躁狂症患者的临床效果

Clinical effects of Aripiprazole combined with Lithium carbonate in treatment of patients with acute mania

目的:观察阿立哌唑联合碳酸锂治疗急性躁狂症患者的临床效果。方法:选取73例急性躁狂症患者作为研究对象,按随机数字表法将其分为对照组36例和研究组37例。两组均使用氯氮平治疗,在此基础上,对照组使用碳酸锂治疗,研究组在对照组基础上联合阿立哌唑治疗,比较两组病情严重程度、临床疗效和用药期间不良反应发生情况。结果:治疗2、6周后,研究组倍克-拉范森躁狂量表评分低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为94.59%(35/37),高于对照组的75.00%(27/36),差异有统计学意义(P<0.05);两组治疗前后TESS评分比较,差异均无统计学意义(P>0.05)。结论:阿立哌唑联合碳酸锂治疗急性躁狂症患者,优势明显,可有效改善病情,提高临床效果,安全性较高。

Objective:To explore clinical effects of Aripiprazole combined with Lithium carbonate in treatment of patients with acute mania.Methods:73 patients with acute mania were selected as the research objects,and were divided into control group(36 cases)and study group(37 cases)according to the random number table method.Both groups were treated with Clozapine.On this basis,the control group was treated with Lithium carbonate,while the study group was treated with Aripiprazole on the basis of the control group.The severity of the disease,clinical effects and adverse reactions during medication were compared between the two groups.Results:2 and 6 weeks after the treatment,the score of the BechRafaelsen mania rating scale in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the study group was 94.59%(35/37),which was higher than 75.00%(27/36)in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the TESS scores between the two groups before and after the treatment(P>0.05).Conclusions:Aripiprazole combined with lithium carbonate has obvious advantages in the treatment of the patients with acute mania.It can effectively improve the conditions,improve the clinical effects,and has high safety.