摘要
目的研究不同病理级别胶质瘤中人表皮生长因子受体-4(HER4)的表达情况。方法选取不同病理级别胶质瘤标本88例,用免疫组织化学法和实时荧光定量聚合酶链式反应(PCR)法分别检测HER4的表达水平。结果HER4阳性表达主要定位于细胞质和细胞核。随着胶质瘤病理级别的升高,HER4的表达也相应增加。结论HER4有可能在胶质瘤的发生、发展过程中发挥重要调节作用,有望成为评价胶质瘤恶性程度的重要生物学指标。
【Objective】To study the expression of HER4 in different pathological grade gliomas.【Methods】The expression of HER4 was detected by immunohistochemistry and real-time fluorescence quantitative PCR in 88 glioma samples of different pathological grades.【Results】The positive expression of HER4 was mainly localized in cytoplasm and nucleus.The expression of HER4 increased with the increase of pathological grade of glioma.【Conclusion】HER4 may play an important role in the occurrence and development of gliomas,and it can be used as an important biological index to evaluate the malignant degree of gliomas.
作者
张新鹃
王海凤
孙龙
姜旭光
ZHANG Xinjuan;WANG Haifeng;SUN Long;JIANG Xuguang(Departmen of Western Medicine Education,Shandong College of Traditional Chinese Medicine,Yantai,Shandong 264199,China;Departmen of Neurosurgery,Linyi Central Hospital,Yishui,Shandong 276400,China)
出处
《中国医学工程》
2020年第12期1-3,共3页
China Medical Engineering
基金
山东省高等学校科技计划项目(J16LL59)
山东中医药高等专科学校校级科研基金项目(2016ky009)。
