摘要
Intra-abdominal infection(IAI)is a deadly condition in which the outcome is associated with urgent diagnosis,assessment and management,including fluid resuscitation,antibiotic administration while obtaining further laboratory results,attaining precise measurements of hemodynamic status,and pursuing source control.This last item makes abdominal sepsis a unique treatment challenge.Delayed or inadequate source control is an independent predictor of poor outcomes and recognizing source control failure is often difficult or impossible.Further complicating issue in the debate is surrounding the timing,adequacy,and procedures of source control.This review evaluated and summarized the current approach and challenges in IAI management,which are the future research directions.
基金
The work was supported by the National Natural Science Foundation of China(81801971)
National Major Scientific and Technological Special Project for"Significant New Drugs Development"(2017ZX09304005-002)
Key Project of Science Foundation of the 12th Five-Year Plan(BNJ13J002)
and Nanjing Science and Technology Development Project(201803051).
