摘要
微小RNA(microRNA)在神经系统疾病分子调控中起关键作用,而miRNA的分子机制与缺血缺氧性脑病的发生与发展密切相关。近来有研究报道,多种miRNA分子可通过与靶mRNA的完全互补结合或不完全互补结合来抑制靶mRNA,甚至降解靶mRNA。因此,miRNA对缺氧缺血性脑病相关mRNA的研究颇具重要意义。本文主要从miRNA的分子机制、功能及调控对缺血缺氧性脑病的影响等方面进行简要综述。
MicroRNA(miRNA)plays a key role in the molecular regulation of neurological diseases,and the molecular mechanism of miRNA is closely related to the occurrence and development of Hypoxic-Ischemic Encephalopathy.Recently,it has been reported that various miRNA molecules can inhibit target mRNA and even degrade target mRNA by changing the complete complementary or incomplete complementary binding to the target mRNA.Therefore,miRNA is of great significance for the study of mRNA related to Hypoxic-Ischemic Encephalopathy.This article briefly reviews the molecular mechanisms,functions and regulation of miRNAs on Hypoxic-Ischemic Encephalopathy.
作者
刘春阳
曾会勤
刘敏
哈什姆
刘泽源
韩语纯
徐辉
LIU Chun-yang;ZENG Hui-qin;LIU Min;Hisham Alward;LIU Ze-yuan;HAN Yu-chun;XU Hui(School of Basic Medical Science, Jiamusi University, Jiamusi 154007, China;The First Affiliated Hospital of Xiamen University, Xiamen 361003, China;Beijing Friendship Hospital, Capital Medical University, Beijing100000, China;The First Hospital of Jilin University, Changchun 130000, China)
出处
《海南医学院学报》
CAS
2020年第24期1907-1913,共7页
Journal of Hainan Medical University
基金
国家自然科学基金(30671803,81273174)
国家级大学生创新创业项目(201810222013)。
关键词
微小RNA
缺氧缺血性脑病
新生儿
调控分子机制
生物信息学
MicroRNAs
Hypoxic-Ischemic Encephalopathy
Neonatal
Regulatory molecular mechanisms
Bioinformatics
