甲泼尼龙冲击递减法治疗重症过敏性紫癜的临床效果

Clinical Effect of Methylprednisolone Pulse Diminishing Therapy on Severe Henoch-schonlein Purpura

目的观察甲泼尼龙冲击递减疗法治疗重症过敏性紫癜的效果。方法将2016年12月—2019年12月收治的80例重症过敏性紫癜患者随机分为两组,每组40例。对照组行甲泼尼龙常规治疗,观察组行甲泼尼龙冲击递减法治疗。比较两组的疗效、住院时间及临床症状改善时间等指标。结果 (1)观察组总有效率为95.0%(38/40),明显高于对照组的75.0%(30/40),比较差异有统计学意义(P <0.05);(2)观察组住院时间、腹痛缓解时间、皮疹消退时间及关节肿痛消失时间分别为(10.8±2.2)、(2.8±0.6)、(6.5±1.1)、(3.1±0.5)d,均短于对照组的(17.2±2.5)、(4.6±0.9)、(8.9±1.5)、(5.9±0.8)d,比较差异均有统计学意义(P <0.05)。结论甲泼尼龙冲击递减法可有效治疗重症过敏性紫癜。

Objective To observe the effect of methylprednisolone pulse diminishing therapy on severe henoch-schonlein purpura.Methods 80 patients with severe allergic purpura admitted to our hospital from December 2016 to December 2019 were randomly divided into two groups,40 cases in each group.The control group received conventional methylprednisolone treatment,and the observation group underwent the methylprednisolone pulse diminishing method.The curative effect,hospitalization time and improvement time of clinical symptoms were compared between the two groups.Results(1)The total effective rate of the observation group was 95.0%(38/40),which was significantly higher than 75.0%(30/40)of the control group,and the difference was statistically significant(P<0.05),(2)The hospitalization time,abdominal pain relief time,rash resolution time,and joint swelling and pain disappearing time of the observation group were(10.8±2.2),(2.8±0.6),(6.5±1.1),(3.1±0.5)d,respectively,which were shorter than those of the control group(17.2±2.5),(4.6±0.9),(8.9±1.5),(5.9±0.8)d,the differences were statistically significant(P<0.05).Conclusion Methylprednisolone impact diminishing method can effectively treat severe allergic purpura.