Hippo激酶级联调控心肌缺血再灌注损伤炎症细胞表型

Hippo Kinase Cascade Regulates Inflammatory Cell Phenotype in Myocardial Ischemia-Reperfusion Injury

血管再通是目前治疗冠状动脉狭窄或梗塞的关键措施,积极有效的防治缺血再灌注损伤对患者的预后具有及其重要的意义。免疫炎性损伤被认为是心肌缺血损伤的重要危害因子,如何减轻炎症反应在这损伤中起着关键的作用。Hippo激酶级联能够通过各种信号通路并结合多个下游靶点对炎症细胞的增殖、分化及表型进行调控,从而降低炎症程度,达到抑制细胞的损伤。文章对Hippo激酶级联在调控炎症反应中的作用进行综述。

Vascular recanalization is a key measure in the treatment of coronary artery stenosis or infarction.It is of great significance for the prognosis of patients to actively and effectively prevent ischemia reperfusion injury.Immune inflammatory injury is considered as an important risk factor for myocardial ischemic injury.How to reduce inflammatory response plays a key role in this injury.Hippo kinase cascade regulates the proliferation,differentiation,and phenotype of inflammatory cells through a variety of signaling pathways combined with multiple downstream targets,thereby reducing inflammation and inhibiting cell damage.This paper reviews the role of Hippo kinase cascade in the regulation of inflammatory response.