摘要
环状RNA(circular RNA,circRNA)是一类非线性的内源性非编码RNA,经反向剪接形成,无5′端帽子结构和3′端多聚腺苷酸尾巴结构,但在生物体中能稳定存在.近年来,随着高通量测序技术的快速发展及生物信息学方法的不断创新,在诸多物种的细胞中找到了大量的内源性circRNA,某些内源性circRNA还表现出物种间保守性、阶段特异性和组织特异性的特点.越来越多的研究证实,circRNA在生物体的各种生物学过程中有着非常重要的调控功能.本文综述了circRNA的发现、生成、分类、特征、功能和其在猪上的研究进展,并提出开展circRNA对猪重要经济性状的调控作用及分子机制研究的展望,以期为今后从circRNA层面为猪的遗传改良提供参考.
Circular RNA(circRNA)is a kind of non-linear endogenous and non-coding RNA,which is formed by reverse splicing.It has no 5′cap structure and 3′polyadenylate tail structure.However,it can stably exist in many organisms.Recently,with the rapid development of high-throughput sequencing technology and the continuous updating of bioinformatics methods,a large amount of endogenous circRNA have been found in cells of many species.Some endogenous circRNA display species conservation,stage specificity and tissue specificity.Many studies have proved that circRNA play important regulatory roles in different biological processes of organisms.In this paper,the discovery,generation,classification,characteristics,function of circRNA and its research progress in pigs are reviewed.The regulation mechanism of circRNA to important economic traits in pigs and the prospect of molecular mechanism research are also reviewed,which is aim to provide fundamental information for genetic improvement of pigs from the perspective of circRNA.
作者
闫尊强
姜天团
孙文阳
王鹏飞
黄晓宇
杨巧丽
胡慧艳
李守湖
滚双宝
YAN Zun-qiang;JIANG Tian-tuan;SUN Wen-yang;WANG Peng-fei;HUANG Xiao-yu;YANG Qiao-li;HU Hui-yan;LI Shou-hu;GUN Shuang-bao(College of Animal Science and Technology,Gansu Agricultural University,Lanzhou 730070,China;Gansu Research Center for Swine Production Engineering and Technology,Lanzhou 730070,China;College of Animal Science and Technology,Hebei Agricultural University,Baoding 071000,China;College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China)
出处
《甘肃农业大学学报》
CAS
CSCD
北大核心
2020年第6期1-9,共9页
Journal of Gansu Agricultural University
基金
甘肃农业大学公招博士科研启动基金项目(GAU-KYQD-2019-07)
国家自然科学基金项目(31660646
31960646)。