社区老年高尿酸血症患者尿微量白蛋白水平及临床意义分析

Analysis of urinary microalbumin level and its clinical significance in elderly patients with hyperuricemia in the community

目的:分析348例社区老年高尿酸血症(HUA)患者尿微量白蛋白水平及其在肾功能评估中的临床意义。方法:以社区348例老年HUA患者为研究对象,年龄65~88岁,平均年龄(70.22±4.41)岁;其中男性232例,女性116例。比较HUA合并和未合并其他相关疾病组的尿微量白蛋白、血肌酐、胱抑素-C的水平。结果:31.6%老年HUA患者的尿微量白蛋白水平高于正常值。HUA合并和未合并其他相关疾病组之间的血清肌酐和胱抑素-C水平差异无统计学意义(P>0.05),合并疾病组患者的尿微量蛋白水平明显高于未合并疾病组组,差异具有统计学意义(P<0.05)。结论:社区老年HUA患者尿微量白蛋白水平控制并不理想,相比于血清肌酐和胱抑素-C,尿微量白蛋白在评估高尿酸血症合并其他相关疾病老年患者的早期肾功能具有更重要的临床意义。

Objective:To analyze the level of urinary microalbumin in 348 elderly community patients with hyperuricemia(HUA)and its clinical significance in the evaluation of renal function.Methods:Three hundred and forty-eight elderly HUA patients in the community were taken as the research objects,the age was from 65 to 88 years old,and the average age was(70.22±4.41)years old;among them,232 were males and 116 were females.The levels of urinary microalbumin,serum creatinine and cystatin-C in HUA with and without other related diseases were compared.Results:Urinary microalbumin in 31.6%of elderly HUA patients was higher than normal.There was no statistically significant difference in serum creatinine and cystatin-C between the HUA groups with and without other related diseases(P>0.05),and the urine microprotein level of patients in the combined disease group was significantly higher than that in the non-combined disease group,and the difference was statistically significant(P<0.05).Conclusion:The control of urine microalbumin levels in elderly HUA patients in the community is not ideal,compared with serum creatinine and cystatin-C,urine microalbumin has more important clinical significance in evaluating the early renal function of elderly patients with HUA and other related diseases.