摘要
外泌体是细胞分泌的一种微小囊泡,内含多种生物分子,在细胞通信中发挥重要作用。环状RNA(circRNA)是外泌体中的一类核酸分子,是以共价键结合的闭合环状RNA,无5'端帽子和3'端poly(A)尾,主要充当微小RNA(miRNA)海绵,在基因表达中发挥重要的调控作用。外泌体来源的circRNA可调节肿瘤的增殖、转移和耐药,并且大量存在于肿瘤患者的血浆中,或可作为肿瘤早期诊断和预后评估的生物标志物。文章主要介绍外泌体circRNA在不同肿瘤发生、发展中的生物学功能,为外泌体来源的circRNA在肿瘤诊疗领域中的应用提供依据。
Exosomes refer to small vesicles secreted by cells,containing various molecules and playing a role in intercellular communication.Circular RNA is a class of nucleic acid molecules contained in exosomes.It forms circular structures by covalent bonds without a 5'cap and a 3'poly(A)tail,mainly functioning as miRNA sponges and playing an important regulatory role in gene expression.Exosome-derived circRNA can promote tumor proliferation,metastasis and drug resistance,which are enriched in plasma and may be served as biomarkers for diagnosis and prognosis in early tumor.This review highlights the biological functions of exosomal circRNA in the onset and development of different tumors and provides a reference for the application of exosome-derived circRNA in tumor diagnosis and treatment.
作者
杨文静
吕丽华
姚嘉怡
王皓
张春燕
王蓓丽
潘柏申
郭玮
YANG Wenjing;LU Lihua;YAO Jiayi;WANG Hao;ZHANG Chunyan;WANG Beili;PAN Baishen;GUO Wei(Department of Clinical Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Clinical Laboratory,Xiamen Branch,Zhongshan Hospital,Fudan University,Xiamen 361015,Fujian,China)
出处
《检验医学》
CAS
2020年第12期1213-1219,共7页
Laboratory Medicine
基金
国家自然科学基金面上项目(81772263)
国家自然科学基金面上项目(81972000)
国家自然科学基金青年基金(81902139)
上海市科委临床医学领域研究项目(16411952100)
上海市临床重点专科建设项目(医学检验科)
2017年上海市“上海青年临床医技人才(临床检验专业)培养资助计划”项目
复旦大学附属中山医院院内临床研究项目(2018ZSLC05)
厦门市医疗卫生重点项目(YDZX20193502000002)。
