259例类风湿性关节炎患者用药分析

Analysis of Medication Utilization in 259 Patients with Rheumatoid Arthritis

目的:分析类风湿性关节炎(RA)患者用药情况,为临床合理用药提供参考。方法:从医院信息系统中提取2018年9月~2019年4月于我院就诊的259例RA患者临床资料,统计并分析其基本信息及处方用药。结果:259例患者男女之比约为1∶5.2;患者确诊RA年龄集中在40~55岁;分析治疗RA处方药物,甲氨蝶呤的使用频率为42.08%,远低于来氟米特的使用频率60.23%;非甾体抗炎药(NSAIDs)使用频率超过30%。护胃药物选择主要为质子泵抑制剂。2张处方中患者激素使用量超过10 mg/d。15例患者的治疗方案仅植物制剂或植物制剂合用NSAIDs控制病情。14例患者同时服用激素类药物与NSAIDs。结论:RA主要发病人群是中老年女性患者,临床用药中甲氨蝶呤使用率偏低,护胃药选择欠妥,激素及植物制剂应用的合理性有待提高。

Objective:To analyze the medication status of rheumatoid arthritis(RA)patients,and to provide reference for clinical rational drug use.Methods:The clinical data of 259 patients with RA in our hospital from September 2018 to April 2019 were extracted from hospital information system,and their basic information and prescription medication were analyzed.Results:The ratio of male to female in 259 cases was 1 to 5.2.The age of diagnosis of RA was mainly from 40 to 55 years old.The useage frequency of methotrexate was 42.08%,far lower than that of leflunomide(60.23%),while non-steroidal anti-inflammatory drugs(NSAIDs)was more than 30%.Proton pump inhibitors were the main choice for gastic protection drugs.There were two prescriptions showed patients taking hormones more than 10 mg/d.There were 15 patients treated with plant preparation only or combined with NSAIDs.There were 14 patients took hormone and NSAIDs simultaneously.Conclusion:The main RA patients are middle-aged and elderly female.The clinical use of methotrexate is low,the choice of stomach protection drug is not appropriate,and the application rationality of hormone and botanical preparation is necessary to be improved.