银黄洗剂灌注联合间歇性负压吸引治疗糖尿病足病湿热毒盛证创面的效果

Clinical Observation of Yinhuang Lotion Perfusion Combined with Intermittent Vacuum Aspiration in the Treatment of Diabetic Foot Disease

目的:观察银黄洗剂灌注联合间歇性负压吸引治疗糖尿病足病湿热毒盛证创面的效果。方法:将56例糖尿病足病湿热毒盛证患者随机分为治疗组及对照组各28例,治疗组予以银黄洗剂灌注联合间歇性负压吸引治疗,对照组予以无菌生理盐水灌注联合间歇性负压吸引治疗,疗程均为5 d,观察治疗前后的创面情况(新生肉芽组织覆盖率)及实验室指标(白细胞计数、超敏C反应蛋白及白细胞介素-1)的变化情况。结果:治疗后,治疗组新生肉芽组织覆盖率明显大于对照组(P<0.05),两组白细胞计数、超敏C反应蛋白及白细胞介素-1均较治疗前明显降低,且治疗组较对照组降低更明显(P<0.05)。结论:银黄洗剂灌注联合间歇性负压吸引治疗糖尿病足病湿热毒盛证创面疗效明显,可显著改善创面感染情况,效果优于无菌生理盐水灌注联合间歇性负压吸引治疗。

Objective To observe the efficacy of Yinhuang lotion infusion combined with intermittent negative pressure suction in the treatment of diabetic foot diseases.Methods There were 56 patients with diabetic foot syndrome of damp-heat intoxication.They were randomly divided into treatment group and control group,which with 28 cases each.The treatment group was treated with Yinhuang lotion perfusion combined with intermittent negative pressure suction therapy,while the control group was treated with sterile physiological saline perfusion combined with intermittent negative pressure suction therapy.The course of treatment was 5 days.The changes of the wound surface(the coverage rate of the new granulation tissue)and the laboratory indexes(WBC and hs-CRP)were observed.Results The coverage rate of new granulation tissue in the treatment group was significantly higher than that in the control group(P<0.05).WBC and hs-CRP in the treatment group and the control group were significantly lower than those in the control group(P<0.05).Conclusion Yinhuang lotion infusion combined with intermittent negative pressure suction for the treatment of diabetic foot disease with dampness-heat intoxication syndrome has obvious curative effect.It can significantly improve the condition of wound infection and the effect is better than that of sterile physiological saline infusion combined with intermittent negative pressure suction.