阳和汤加减辅助治疗对肾虚寒湿型强直性脊柱炎患者血清TNF-α、SOST和BMP-2水平的影响

Effects of modified Yanghe decoction adjuvant therapy on serum TNF-α,SOST and BMP-2 levels in patients with ankylosing spondylitis of kidney deficiency and cold dampness type

目的探讨阳和汤加减辅助治疗肾虚寒湿型强直性脊柱炎(AS)患者的临床效果。方法将88例肾虚寒湿型AS患者按照随机数字表法分为对照组(44例,常规西医治疗)与观察组(44例,常规西医治疗+阳和汤加减治疗)。比较两组的临床效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的中医症候积分均降低,且观察组低于对照组(P<0.05)。治疗后,两组的BASDAI、BASFI评分、Schober试验、CRP、TNF-α、SOST、BMP-2及ESR水平均改善,且观察组优于对照组(P<0.05)。结论阳和汤加减辅助治疗肾虚寒湿型AS的效果显著。

Objective To investigate the effect of modified Yanghe decoction adjuvant therapy in the treatment of patients with ankylosing spondylitis(AS)of kidney deficiency and cold dampness type.Methods A total of 88 patients with AS of kidney deficiency and cold dampness type were divided into control group(44 cases,conventional western medicine treatment)and observation group(44 cases,conventional western medicine treatment+modified Yanghe decoction treatment)by random number table method.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the TCM symptom score in the two groups decreased,and that in the observation group was lower than the control group(P<0.05).After treatment,BASDAI and BASFI score,Schober test,the levels of CRP,TNF-α,SOST,BMP-2 and ESR in the two groups improved,and those in the observation group were better than the control group(P<0.05).Conclusion Modified Yanghe decoction adjuvant therapy on AS of kidney deficiency and cold dampness type has a significant effect.