依折麦布联合他汀类药物对急性冠脉综合征患者血脂水平及炎症因子水平的改善作用

Improvement effect of ezetimibe combined with statins on the levels of blood lipid and inflammatory factors in patients with acute coronary syndrome

目的探究依折麦布联合他汀类药物对急性冠脉综合征(ACS)患者血脂水平及炎症因子水平的改善作用。方法随机选取我院收治的110例ACS患者作为研究对象,按照随机数字表法将其分为对照组(55例)和观察组(55例)。对照组患者使用他汀类药物进行治疗,观察组患者使用依折麦布联合他汀类药物进行治疗。比较两组治疗前、后的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、基质金属蛋白酶9(MMP-9)、尿微量白蛋白胆固醇(UMA)、降钙素原(PCT)水平及不良反应及主要不良心血管事件(MACE)发生情况。结果治疗后,两组的TC、LDL-C、TG、hs-CRP、TNF-α、IL-6、MMP-9、UMA、PCT水平均降低,且观察组低于对照组(P<0.05)。两组的不良反应、MACE总发生率无显著差异(P>0.05)。结论依折麦布联合他汀类药物治疗ACS能够显著改善患者的血脂水平及炎性因子水平,值得推广。

Objective To explore the improvement effect of ezetimibe combined with statins on the levels of blood lipid and inflammatory factors in patients with acute coronary syndrome(ACS).Methods A total of 110 ACS patients admitted in our hospital were randomly selected as study subjects,and the patients were divided into control group(55 cases)and observation group(55 cases)according to the random number table method.Patients in the control group were treated with statins,and patients in the observation group were treated with ezetimibe combined with statins.The levels of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),high sensitivity C-reactive protein(hsCRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9),urine microalbumin(UMA)and procalcitonin(PCT)before and after treatment,the occurrence of adverse reactions and major adverse cardiovascular events(MACE)were compared between the two groups.Results After treatment,the levels of TC,LDL-C,TG,hs-CRP,TNF-α,IL-6,MMP-9,UMA and PCT in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).There were no significant differences in the total incidence of adverse reactions and MACE between the two groups(P>0.05).Conclusion Ezetimibe combined with statins in the treatment of ACS can significantly improve the levels of blood lipid and inflammatory factors,which is worthy of promotion.