10 mg/d瑞舒伐他汀钙治疗老年冠心病合并高脂血症患者的效果

Effect of 10 mg/d rosuvastatin calcium on elderly patients with coronary heart disease and hyperlipidemia

目的探究10 mg/d瑞舒伐他汀钙治疗老年冠心病合并高脂血症患者的效果。方法选取2018年5月至2019年10月在本院进行治疗的100例老年冠心病合并高脂血症患者为研究对象,按照入院顺序将其分为观察组(n=50,10 mg/d瑞舒伐他汀钙)和对照组(n=50,5 mg/d瑞舒伐他汀钙)。比较两组的治疗效果。结果治疗后,观察组TC、TG、LDL-C、HDL-C水平、颈动脉斑块面积及颈动脉内膜-中膜厚度优于对照组(P<0.05)。治疗后,观察组的FMD、NO水平高于对照组,ET-1、BNP水平低于对照组(P<0.05)。治疗后,观察组的IGF-1水平高于对照组,s CD40L水平低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。结论10 mg/d瑞舒伐他汀钙治疗老年冠心病合并高脂血症效果显著,能够改善患者的血脂水平,缓解炎症反应,提高治疗安全性,值得研究和推广。

Objective To investigate the effect of 10 mg/d rosuvastatin calcium on elderly patients with coronary heart disease and hyperlipidemia.Methods A total of 100 elderly patients with coronary heart disease and hyperlipidemia who were treated in our hospital from May 2018 to October 2019 were selected as study objects and divided into observation group(n=50,10 mg/d rosuvastatin calcium)and control group(n=50,5 mg/d rosuvastatin calcium)according to the order of admission.The therapeutic effects of the two groups were compared.Results After treatment,the levels of TC,TG,LDL-C,HDL-C,carotid plaque area and carotid intima-media thickeness in the observation group were better than those in the control group(P<0.05).After treatment,FMD and NO levels in the observation group were higher than those in the control group,while ET-1 and BNP levels were lower than those in the control group(P<0.05).After treatment,IGF-1 level in the observation group was higher than that in the control group,and sCD40 L level was lower than that in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).Conclusion 10 mg/d rosuvastatin calcium on elderly patients with coronary heart disease and hyperlipidemia has significant therapeutic effect,it can ameliorate the blood lipid level of patients,relieve inflammation,and improve the safety of treatment,which is worthy of research and promotion.