微流控芯片通用性微阀的设计实现与性能

Design and Performance Research on Universal Micro Valve for Microfluidic Chip

随着微流控技术越来越广泛的应用于生物医药、化学分析等领域,该技术的实现载体——微流控芯片成为了研究热点和难点,而微阀作为芯片内流体控制的关键部件,其性能直接决定了芯片的可用性。为了实现芯片液路切换和密闭性等功能,同时在保证可靠性的前提下兼具通用性和低成本,提出了一种可靠性高、通用性强且成本低廉的机械式旋转微阀,其结构保证了自密封性。通过外部设备驱动旋转,可以精确控制多个流道通路的开闭和切换,通过机械接口的设计,其易于集成在多类微流控芯片上。通过静力学仿真分析和气密性实验。结果表明:微阀结构预紧力分布均匀,密封垫片变形合理,在0.16 MPa的截止压强范围内可以实现零泄露,验证了微阀的有效性和可用性。

As the microfluidic technology is increasingly utilized in biomedicine,chemical analysis and other fields,the microfluidic chips,the carrier of this technology,has become a hotspot and a difficulty of research.The micro valve,a key component for the fluid control in chips,directly determines the usability of the chip.In order to implement the functions of channels switching and sealing on chip,and to be universal and low cost under the premise of high reliability,a mechanical rotary micro valve with high reliability,versatility and low cost was proposed.It s structure ensured self-sealing,and it can precisely control the opening or closing and switching of multiple flow channels by external equipments.The design of a mechanical interface made it easy to integrate in many types of microfluidic chips.The results of the static simulation analysis and air tightness test show that the pre-tightening force of the micro valve structure is equally distributed,the gasket is deformed reasonably,and zero leakage can be realized within the cut-off pressure range of 0.16 MPa,which verifies the effectiveness and availability of the micro valve.