高龄孕产妇血清ApoB IL-18表达与产后抑郁相关性分析

The Correlations Between the Expressions of ApoB IL-18 and Postpartum Depression in Elderly Pregnant Women

目的:探究载脂蛋白B(ApoB)、白细胞介素-18(IL-18)在高龄孕产妇血清中的表达水平与产后抑郁(PPD)的相关性。方法:于2016年1月至2019年6月本院分娩,且在产后42d按嘱随访的产妇中,选取符合抑郁诊断标准的85例产妇进行研究,称PPD组;并选取同期随访的87例健康产妇进行对照研究,称正常组。比较两组产妇一般资料;采用免疫透射比浊法测定所有产妇血清APOB水平;以酶联免疫吸附法(ELISA)检测所有产妇血清IL-18水平;采用爱丁堡产后抑郁量表(EPDS)评定所有产妇抑郁状况;Pearson法分析PPD患者血清ApoB、IL-18水平、EPDS评分与总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)的关系及血清ApoB、IL-18水平与EPDS评分相关性;Logistic回归分析PPD发生的影响因素。结果:PPD组产妇血清TC、HDL-C水平明显低于正常组(P<0.05),PPD组患者血清ApoB、IL-18水平、EPDS评分均明显高于正常组(P<0.05);PPD患者血清ApoB、IL-18水平、EPDS评分与TC、HDL-C含量均呈负相关(P<0.05),血清ApoB、IL-18水平与EPDS评分均呈正相关(P<0.05);TC、HDL-C水平高是影响PPD发生的保护因素(P<0.05),ApoB、IL-18水平高是影响PPD发生的危险因素(P<0.05)。结论:产后抑郁女性血清ApoB、IL-18表达水平上调,两者与抑郁症状程度相关,可能在PPD发生发展中发挥重要作用。

Objective:To explore the correlation between the expression levels of apolipoprotein B(ApoB)and interleukin-18(IL-18)in the serum of elderly pregnant women and postpartum depression(PPD).Methods:From January 2016 to June 2019,85 women who met the diagnostic criteria for depression were selected and followed up as required for 42 days after delivery,which was called PPD group;and 87 cases of pregnant women who did not meet the diagnostic criteria for depression during the same period of follow-up were selected for a controlled study,which was made the normal group.The general data of the two groups were compared and analyzed.The level of serum ApoB of all pregnant women was measured by immunoturbidimetry.The level of IL-18 was detected by enzyme-linked immunosorbent assay(ELISA).The Edinburgh Postpartum Depression Scale(EPDS)was used to evaluate the depression status of all pregnant women.Pearson's method was used to analyze the relationships between the levels of serum ApoB,IL-18,EPDS score and total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),and the correlations between the levels of serum ApoB,IL-18 and EPDS score.And the influencing factors of PPD were analyzed by Logistic regression.Results:The levels of serum TC and HDL-C in PPD group were significantly lower than those in normal group(P<0.05),and the levels of ApoB and IL-18,and EPDS score in PPD group were significantly higher than those in normal group(P<0.05).The levels of serum ApoB and IL-18,EPDS score in PPD patients were negatively correlated with TC and HDL-C(P<0.05),and the levels of serum ApoB and IL-18 were positively correlated with EPDS score(P<0.05).TC,HDL-C levels were protective factors of PPD(P<0.05),and high levels of ApoB and IL-18 were risk factors of PPD(P<0.05).Conclusion:The expression levels of ApoB and IL-18 in serum of women with postpartum depression are up-regulated,which may be related to the degree of depressive symptoms.They may play an important role in the occurrence and development of PPD.