BiPAP无创呼吸机治疗COPD急性加重期患者的疗效及安全性

Efficacy and Safety Analysis of BiPAP Non-Invasive Ventilator in Patients with Acute Exacerbation of COPD

目的:研究慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)急性加重期患者治疗中双水平气道内正压(Bi-Level Positive Airway Pressure,BiPAP)无创呼吸机的应用效果及安全性。方法:采用回顾性分析方法,研究对象为2016年6月至2019年6月入院的120例COPD急性加重期患者,按照不同治疗方式分为两个小组,一个小组为对照组,另一个小组为研究组,各60例;对照组行常规治疗,研究组基于常规治疗选用BiPAP无创呼吸机治疗;比较两组治疗前后血气分析指标(动脉血氧分压、二氧化碳分压)、D-二聚体、水平与治疗后总有效率、不良反应(头晕、恶心、呕吐、腹泻)发生率。结果:研究组治疗后动脉血氧分压、二氧化碳分压、D-二聚体、总有效率及不良反应发生率依次为(95.14±12.31)mmHg、(47.97±6.03)mmHg、(30.09±4.97)μg/L、(87.14±19.98)μg/L、96.67%、5.00%,对照组治疗后各项指标依次为(86.43±10.08)mmHg、(60.15±6.81)mmHg、(41.85±5.22)μg/L、(109.03±27.14)μg/L、85.00%、6.67%。研究组较对照组治疗后动脉血氧分压、总有效率更高,二氧化碳分压、D-二聚体水平更低(P<0.05);两组治疗后不良反应发生率无差异(P>0.05)。结论:COPD急性加重期患者治疗中BiPAP无创呼吸机的应用效果显著,可有效改善患者的血气指标,还可减轻炎症反应,且不良反应少,安全性高。

Objective:To study the application effect and safety of bi-level positive airway pressure(BiPAP)non-invasive ventilator in the treatment of chronic obstructive pulmonary diseases(COPD)patients in the phase of exacerbation.Methods:A retrospective analysis method was adopted.The study objects were 120 patients with COPD in the phase of acute exacerbation who admitted from June 2016 to June 2019.They were divided into control group and study group according to different treatment methods,60 cases in each;the control group received conventional treatment,and the study group was administrated BiPAP non-invasive ventilator therapy based on conventional treatment.The blood gas analysis indicators(arterial oxygen pressure,carbon dioxide partial pressure),and D-dimer were compared between the two groups before and after treatment,E-selectin levels and the total effective rate after treatment,the incidence of adverse reactions(dizziness,nausea,vomiting,diarrhea).Results:After treatment,the arterial blood oxygen partial pressure,carbon dioxide partial pressure,D-dimer,hs-CRP,total effective rate and incidence of adverse reactions were(95.14±12.31)mmHg,(47.97±6.03)mmHg,(30.09±4.97)μg/L,(13.68±8.15)mg/L,96.67%,5.00%,the indexes of the control group after treatment are(86.43±10.08)mmHg,(60.15±6.81)mmHg,(41.85±5.22)μg/L,(19.25±10.25)mg/L,85.00%,6.67%.Compared with the control group,the study group had higher arterial blood oxygen partial pressure and total effective rate,and lower carbon dioxide partial pressure,D-dimer,and hs-CRP levels(P<0.05);the incidence of adverse reactions after treatment in both groups was not different(P>0.05).Conclusion:BiPAP non-invasive ventilator has a significant effect in the treatment of patients with acute exacerbation of COPD.It can effectively improve the blood gas index of patients,reduce the inflammatory response,and has fewer adverse reactions and high safety.