颅脑外伤患者血清BAC对炎症反应与CT影像特点的影响

Effects of Serum BAC on Inflammation and CT Imaging Characteristics in Patients with Craniocerebral Trauma

目的:探讨颅脑外伤患者血清酒精浓度(BAC)对炎症反应与CT影像特点的影响。方法:选取我院在2018年10月至2019年10月期间收治的颅脑损伤患者106作为研究对象。采用气相色谱法测量患者BAC,根据酒精浓度,将患者分为酒精阳性组(BAC>0.05%)和酒精阴性组(BAC<0.05%),分别为42、64例。所有患者进行CT扫描,比较两组患者血清炎症反应指标水平与CT影像特点。结果:酒精阳性组患者的收缩压、心率及体温显著低于酒精阴性组,而呼吸频率BAC水平却显著高于酒精阴性组(P<0.05)。等级秩和检验结果可知:两组患者在Rotterdam CT评分上比较无统计学意义(P>0.05),但酒精阳性组在Rotterdam CT评分为4、5及6分的患者比例上显著高于酒精阴性组。酒精阳性组患者的血清IL-6、TNF-α、CRP及WBC计数水平显著低于酒精阴性组(P<0.05)。颅脑损伤患者的BAC与血清IL-6、TNF-α、CRP及WBC计数水平均呈正相关,Pearson相关系数r分别为0.931、0.467、0.863、0.935(P<0.05),与Rotterdam CT评分无相关性(P>0.05)。结论:颅脑外伤患者BAC能参与炎症反应的发生过程,能够降低患者的炎症反应程度,但对Rotterdam CT评分影响不明显。

Objective:To explore the effect of serum alcohol concentration(BAC)on inflammation and CT imaging characteristics in patients with craniocerebral trauma.Methods:106 patients with craniocerebral injury admitted in our hospital from October 2018 to October 2019 were selected as the research object.Gas chromatography was used to measure the BAC of the patients.According to the alcohol concentration,the patients were divided into alcohol-positive group(BAC>0.05%)and alcohol-negative group(BAC<0.05%),with 42 and 64 cases respectively.All patients underwent CT scan to compare the serum inflammatory response index level and CT image characteristics of the two groups of patients.Results:The systolic blood pressure,heart rate and body temperature of the alcohol-positive group were significantly lower than those of the alcohol-negative group,while the respiratory frequency BAC level was significantly higher than that of the alcohol-negative group(P<0.05).The results of rank sum test showed that there was no statistically significant difference in Rotterdam CT scores between the two groups(P>0.05),but the proportion of patients with Rotterdam CT scores of 4,5 and 6 in the alcohol-positive group was significantly higher than that in the alcohol-negative group.The levels of serum IL-6,TNF-α,CRP and WBC in the alcohol positive group were significantly lower than those in the alcohol negative group(P<0.05).The BAC of patients with craniocerebral injury was positively correlated with serum IL-6,TNF-α,CRP and WBC counts,and the Pearson correlation coefficient r was 0.931,0.467,0.863,0.935 respectively(P<0.05),which was not related to Rotterdam CT score(P>0.05).Conclusion:BAC can participate in the process of inflammation in patients with cranial head injury and can reduce the degree of inflammation in patients,but it has no obvious influence on Rotterdam CT score.