Histone acetylation and deacetylation in ischemic stroke

Stroke is the second leading cause of death in the world. A significant part of survived people become invalids, dependent on others and in need of outside care. This is a heavy burden for their families and society. The life of patients surviving ischemic stroke(~80% of all strokes) may be subdivided by three main phases:(a) The acute phase that lasts about first 24 hours, when the neurons may be saved and the neuroprotective therapy may be efficient;(b) The early recovery phase that lasts for several days and weeks, when the repair and regeneration processes develop, and partial recovery of brain functions occurs;and (c) The chronic phase(weeks, months and years)。