CD40L/CD40 bidirectional signaling is a major regulator of neuronal morphology in the developing nervous system

Appropriate nervous system function depends on a precise but plastic neural architecture.Neuronal morphology determines how neurons interact with each other and with other cells.Every kind of neuron has its own morphological characteristics,which are determined by both intrinsic and extrinsic factors.In addition to intrinsic genetic programmes and patterns of neural activity,a variety of extrinsic factors regulate the growth and branching of neural processes and synaptogenesis.