Klotho and neurons: mutual crosstalk between autophagy, endoplasmic reticulum, and inflammatory response

Klotho is one of a number of well-known longevity-associated genes.Its depletion in aging or disease may promote several neuropathologies associated with the central nervous system,including hypomyelination and phosphorylation of neurofilaments,synaptic loss and modulation of their plasticity,behavioral impairments,neuroinflammation。